ABCB1 p.Asp164Ala
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PMID: 23733192
[PubMed]
Loo TW et al: "Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface."
No.
Sentence
Comment
102
Mutants I160A, G161V, and D164A were selected for analysis because the recent high-resolution crystal structure of C. elegans P-gp showed that residues at these positions interacted with NBD1 (17).
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ABCB1 p.Asp164Ala 23733192:102:26
status: NEW
PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
Comment
297
In agreement with cysteine mutagenesis results, we found that the D164A mutation did not reduce verapamil-stimulated ATPase activity (23).
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ABCB1 p.Asp164Ala 25987565:297:66
status: NEW298 A difference was that the D164A mutation did not reduce maturation of P-gp (23).
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ABCB1 p.Asp164Ala 25987565:298:26
status: NEW299 The likely explanation is that the D164C mutation was introduced into a Cys-less P-gp background while the D164A mutation was introduced into a wild-type background.
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ABCB1 p.Asp164Ala 25987565:299:107
status: NEW