ABCB1 p.Ile265Ser
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PMID: 23733192
[PubMed]
Loo TW et al: "Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface."
No.
Sentence
Comment
98
Mutants A260L, R262A, T263A, I265S, and Q270A yielded a mixture of mature and immature P-gp (Fig. 1, B and C).
X
ABCB1 p.Ile265Ser 23733192:98:29
status: NEW
PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
Comment
152
Asymmetry of the P-gp Drug Pump Transmission Interfaces JULY 3, 2015ߦVOLUME 290ߦNUMBER 27 JOURNAL OF BIOLOGICAL CHEMISTRY 16957 at SEMMELWEIS UNIV OF MEDICINE on December 4, twenty-eight mutations in ICL2 (A250L, G251V, V253S, A254L, E256A, L258S, I261S, V264S, F267A, G268V, G269V, L274S, R276A, Y277A) inhibited maturation of P-gp (b0d;15% mature P-gp) while four other ICL2 mutations (A2650L, R262A, T263A, and I265S) partially reduced maturation of P-gp (about 55-60% mature P-gp).
X
ABCB1 p.Ile265Ser 25987565:152:430
status: NEW