ABCMdb

ABCC7 p.Pro355Phe

None has been submitted yet.

Publications

PMID: 24876383 [PubMed] Wei S et al: "Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps."

No. Sentence Comment

158 Mean percentages of ATP-free currents afe; S.E. (error bars) were as follows: WT, 0.7 afe; 0.2% (n afd; 5); P355A, 5.0 afe; 1.4% (n afd; 10); P355S, 7.3 afe; 2.0% (n afd; 7); and P355F, 5.4 afe; 1.5% (n afd; 5). Login to comment
165 TABLE 1 Single channel data for multiple Pro-355 CFTR mutants in the absence of ATP and following AMP-PNP activation Conditions were identical to those described in the legend to Fig. 2. n afd; 6 (WT), 7 (P355A), 8 (P355F), and 5 (P355S) patches, respectively. Login to comment
166 WT P355A P355F P355S Mean Po With ATP 0.3074afe;.00514 0.4078 afe; 0.0601 0.4867 afe; 0.0429 0.5212 afe; 0.1048 Without ATP 0.0009 afe; 0.0004 0.0217 afe; 0.0065a 0.0413 afe; 0.0145a 0.0365 afe; 0.0131a With AMP-PNP 0.0127 afe; 0.0114 0.1942 afe; 0.0619a 0.1112 afe; 0.0342a 0.1549 afe; 0.0651a Mean open frequency (sd1a;1 ) With ATP 0.222 afe; 0.021 0.270 afe; 0.028 0.384 afe; 0.049 0.334 afe; 0.059 Without ATP 0.004 afe; 0.001 0.020 afe; 0.002a 0.046 afe; 0.010a 0.028 afe; 0.006a With AMP-PNP 0.013 afe; 0.006 0.131 afe; 0.053a 0.104 afe; 0.035a 0.118 afe; 0.045a a p b0d; 0.05 compared with WT. Login to comment
157 Mean percentages of ATP-free currents afe; S.E. (error bars) were as follows: WT, 0.7 afe; 0.2% (n afd; 5); P355A, 5.0 afe; 1.4% (n afd; 10); P355S, 7.3 afe; 2.0% (n afd; 7); and P355F, 5.4 afe; 1.5% (n afd; 5). Login to comment
164 TABLE 1 Single channel data for multiple Pro-355 CFTR mutants in the absence of ATP and following AMP-PNP activation Conditions were identical to those described in the legend to Fig. 2. n afd; 6 (WT), 7 (P355A), 8 (P355F), and 5 (P355S) patches, respectively. Login to comment