ABCC7 p.Glu115Ser
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PMID: 7518437
[PubMed]
Chang XB et al: "Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion."
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23
1B).A PCR fragment coding for the E115S change was introduced into EL0 to generate a consensus glycosylation site on extracellular loop 1 (ELI, Fig.1B).Fourdifferent PCR fragmentscontaininginsertions coding for peptides NTS, GSNNSH, HRNQS, and NTS were inserted into EL0 at extracytoplasmic loops 2, 3, 5, and 6, respectively, to generate potential glycosylation sites on each putative extracellular loop (Fig. 1B).
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ABCC7 p.Glu115Ser 7518437:23:34
status: NEW64 The extent of sequence perturbation employed to insert these sites rangedfrom a single aminoacid change (E115S)in EL1 to the insertionof 6 additional residues inEL3.
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ABCC7 p.Glu115Ser 7518437:64:105
status: NEW