ABCC7 p.Ser700Asp
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PMID: 9463368
[PubMed]
Sugita M et al: "CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates."
No.
Sentence
Comment
142
To examine this further, we expressed CFTR S-oct-D, which contains eight serine-to-aspartate substitutions in the R domain (S660D, S686D, S700D, S712D, S737D, S768D, S795D and S813D) (Figure 8A).
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ABCC7 p.Ser700Asp 9463368:142:138
status: NEW150 To examine this further, we expressed CFTR S-oct-D, which contains eight serine-to-aspartate substitutions in the R domain (S660D, S686D, S700D, S712D, S737D, S768D, S795D and S813D) (Figure 8A).
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ABCC7 p.Ser700Asp 9463368:150:138
status: NEW
PMID: 7690753
[PubMed]
Rich DP et al: "Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain."
No.
Sentence
Comment
121
The single-channel open-stateprobabil- ity for wild-type CFTR (n = 14), CFTR S-Quad-A (S600A,S737A, S712A,S737A,S768A,S795A,S813A) (n = 7), or CFTR S-Oct-D (S660D,S686D,S700D,S712D,S737D,S768D,S795D,S813D)(n = 7in ATP alone (-PKA);n = 10 inPKA and ATP (+PkX))C1-channels was determined as described under "Experimental Procedures."
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ABCC7 p.Ser700Asp 7690753:121:169
status: NEW123 S795A,S813A) (n = 5).
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ABCC7 p.Ser700Asp 7690753:123:169
status: NEW205 Functional analysisof serine-to-aspartate mutantsof CFTR.A, the changes in SPQ fluorescence ofHeLa cells expressing wild-type CFTR (n = 56), CFTR S-Quad-D (S600D,S737D, S795D,S813D) (n = 24), CFTR S-Hex-D (S660D,S686D,S700D, S712D,S737D,S768D,S795D,S813D)( n = 23), or virus only-infected control cells (n = 53) after substitution of NO; for Iat 0 min.
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ABCC7 p.Ser700Asp 7690753:205:218
status: NEW209 B, time course of current changes inan excised, inside-outmembrane patchfrom a HeLa cell expressingCFTR S-Oct-D (S660D,S686D,S700D,S712D,S737D,S768D,S795D,S813D) C1- chan- nels.ATP (0.88 mM)and PKA (75 m)were added tothe cytosolic(bath) side of the membrane as indicated by the burs.
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ABCC7 p.Ser700Asp 7690753:209:125
status: NEWX
ABCC7 p.Ser700Asp 7690753:209:220
status: NEW213 S737D,S795D,S813D) (n = 37), CFTR S-Oct-D (S660D,S686D,S700D, vitro or in vivo (Figs.6 and 9).
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ABCC7 p.Ser700Asp 7690753:213:55
status: NEWX
ABCC7 p.Ser700Asp 7690753:213:125
status: NEW217 S737D,S795D,S813D) (n = 37), CFTR S-Oct-D (S660D,S686D,S700D, vitro or in vivo (Figs.6 and 9).
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ABCC7 p.Ser700Asp 7690753:217:55
status: NEW