ABCC7 p.Pro1072Ala
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PMID: 22210114
[PubMed]
Dong Q et al: "Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-DeltaF508 processing and alter its gating defect."
No.
Sentence
Comment
90
The P1072A and G1069R variants failed to prevent a ΔF508 effect on interburst interval.
X
ABCC7 p.Pro1072Ala 22210114:90:4
status: NEW155 Other substitutions increased the Po of CFTR-ΔF508 by lengthening the burst duration rather than preventing ΔF508 from A G1069R P1072T hmMSD2 mCFTR hCFTR LNT964-966ISK LNT964-966AAA P1072A hmNBD1/P1072T hmNBD2/P1072T Wild-type ΔF508 D C B hmNBD1 LNT964-966ISK hmNBD2 LNT964-966ISK Fig. 4.
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ABCC7 p.Pro1072Ala 22210114:155:194
status: NEW