ABCC7 p.Pro1072Thr
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PMID: 22210114
[PubMed]
Dong Q et al: "Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-DeltaF508 processing and alter its gating defect."
No.
Sentence
Comment
89
In ICL4, we found that substituting the human P1072 with the mouse T1072 (P1072T) (Fig. 4A) prevented ΔF508 from further increasing the interburst interval (Fig. 4B).
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ABCC7 p.Pro1072Thr 22210114:89:74
status: NEW112 Indeed, an mNBD2 eliminated the protective effect of the ICL3 mutation (LNT964-966ISK), and an mNBD1 eliminated the protective effect of the ICL4 mutant P1072T (Fig. 4B).
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ABCC7 p.Pro1072Thr 22210114:112:153
status: NEW155 Other substitutions increased the Po of CFTR-ΔF508 by lengthening the burst duration rather than preventing ΔF508 from A G1069R P1072T hmMSD2 mCFTR hCFTR LNT964-966ISK LNT964-966AAA P1072A hmNBD1/P1072T hmNBD2/P1072T Wild-type ΔF508 D C B hmNBD1 LNT964-966ISK hmNBD2 LNT964-966ISK Fig. 4.
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ABCC7 p.Pro1072Thr 22210114:155:140
status: NEWX
ABCC7 p.Pro1072Thr 22210114:155:208
status: NEWX
ABCC7 p.Pro1072Thr 22210114:155:222
status: NEW