ABCC7 p.Ser422Pro

[switch to full view]
Comments [show]
Publications
PMID: 22406676 [PubMed] Aleksandrov AA et al: "Allosteric modulation balances thermodynamic stability and restores function of DeltaF508 CFTR."
No. Sentence Comment
112 Combination of introduction of a proline into the Q-loop at position 492 together with I539T to generate ΔF/PT was sufficient to allow a high level of maturation even without further addition of the substitutions in the I539 loop (A534P) to generate ΔF/2PT or also in the RI (S422P and S434P) to generate ΔF/4PT.
X
ABCC7 p.Ser422Pro 22406676:112:286
status: NEW
Login to comment

128 (c) Western blot of WT and ΔF508 CFTR expressed in HEK-293 cells and ΔF508 modified with I539T (ΔF/T), S422P/S434P/S492P/A534P (ΔF/4P), I539T/S492P (ΔF/PT), I539T/S492P/A534P (ΔF/2PT), and I539T/S422P/S434P/S492P/A534P (ΔF/4PT).
X
ABCC7 p.Ser422Pro 22406676:128:118
status: NEW
X
ABCC7 p.Ser422Pro 22406676:128:121
status: NEW
X
ABCC7 p.Ser422Pro 22406676:128:225
status: NEW
Login to comment

178 HEK293 cells were transiently transfected with Cys-less CFTR or Cys-less ΔF508-CFTR in the presence or absence of the 4PT mutations (S422P/S434P/S492P/A534P/I539T), with the Cys pair V510C/G1069C introduced at the CL4/NBD1 interface.
X
ABCC7 p.Ser422Pro 22406676:178:138
status: NEW
Login to comment

PMID: 23104983 [PubMed] He L et al: "Correctors of DeltaF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein."
No. Sentence Comment
122 4PT, S422P/S434P/S492P/ A534P/I539T.
X
ABCC7 p.Ser422Pro 23104983:122:5
status: NEW
Login to comment

148 A) èc;F508 with NBD1-stabilizing mutations: 4S, I539T/G550E/R553M/R555K; èc;RI, deletion of amino acid residues 404-435; 4PT, S422P/S434P/S492P/A534P/I539T.
X
ABCC7 p.Ser422Pro 23104983:148:134
status: NEW
Login to comment

PMID: 25083918 [PubMed] He L et al: "Restoration of NBD1 thermal stability is necessary and sufficient to correct F508 CFTR folding and assembly."
No. Sentence Comment
45 2PT, S492P/A534P/I539T; 4PT, 2PT + S422P/S434P; 3SS, G550E/R553M/R555K; 4SS, 3SS + I539T; ƊRI, deletion of RI amino acids 404-435; combo, ƊRI + 2PT + 3SS.
X
ABCC7 p.Ser422Pro 25083918:45:35
status: NEW
Login to comment

PMID: 26517912 [PubMed] Bose SJ et al: "Exploiting species differences to understand the CFTR Cl- channel."
No. Sentence Comment
120 Hypothesizing that structural differences between human and chicken CFTR account for the thermostability of F508del chicken CFTR, Aleksandrov et al. [41] demonstrated that the F508del revertant I539T and four proline residues at key positions within NBD1 (S422P, S434P, S492P and A534P) were responsible for rescuing the processing, plasma membrane stability and function of human CFTR.
X
ABCC7 p.Ser422Pro 26517912:120:256
status: NEW
Login to comment