ABCC7 p.Ser434Pro
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PMID: 22406676
[PubMed]
Aleksandrov AA et al: "Allosteric modulation balances thermodynamic stability and restores function of DeltaF508 CFTR."
No.
Sentence
Comment
112
Combination of introduction of a proline into the Q-loop at position 492 together with I539T to generate ΔF/PT was sufficient to allow a high level of maturation even without further addition of the substitutions in the I539 loop (A534P) to generate ΔF/2PT or also in the RI (S422P and S434P) to generate ΔF/4PT.
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ABCC7 p.Ser434Pro 22406676:112:296
status: NEW128 (c) Western blot of WT and ΔF508 CFTR expressed in HEK-293 cells and ΔF508 modified with I539T (ΔF/T), S422P/S434P/S492P/A534P (ΔF/4P), I539T/S492P (ΔF/PT), I539T/S492P/A534P (ΔF/2PT), and I539T/S422P/S434P/S492P/A534P (ΔF/4PT).
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ABCC7 p.Ser434Pro 22406676:128:124
status: NEWX
ABCC7 p.Ser434Pro 22406676:128:127
status: NEWX
ABCC7 p.Ser434Pro 22406676:128:231
status: NEW178 HEK293 cells were transiently transfected with Cys-less CFTR or Cys-less ΔF508-CFTR in the presence or absence of the 4PT mutations (S422P/S434P/S492P/A534P/I539T), with the Cys pair V510C/G1069C introduced at the CL4/NBD1 interface.
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ABCC7 p.Ser434Pro 22406676:178:144
status: NEW
PMID: 23104983
[PubMed]
He L et al: "Correctors of DeltaF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein."
No.
Sentence
Comment
122
4PT, S422P/S434P/S492P/ A534P/I539T.
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ABCC7 p.Ser434Pro 23104983:122:11
status: NEW148 A) èc;F508 with NBD1-stabilizing mutations: 4S, I539T/G550E/R553M/R555K; èc;RI, deletion of amino acid residues 404-435; 4PT, S422P/S434P/S492P/A534P/I539T.
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ABCC7 p.Ser434Pro 23104983:148:140
status: NEW
PMID: 25083918
[PubMed]
He L et al: "Restoration of NBD1 thermal stability is necessary and sufficient to correct F508 CFTR folding and assembly."
No.
Sentence
Comment
45
2PT, S492P/A534P/I539T; 4PT, 2PT + S422P/S434P; 3SS, G550E/R553M/R555K; 4SS, 3SS + I539T; ƊRI, deletion of RI amino acids 404-435; combo, ƊRI + 2PT + 3SS.
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ABCC7 p.Ser434Pro 25083918:45:41
status: NEW
PMID: 26517912
[PubMed]
Bose SJ et al: "Exploiting species differences to understand the CFTR Cl- channel."
No.
Sentence
Comment
120
Hypothesizing that structural differences between human and chicken CFTR account for the thermostability of F508del chicken CFTR, Aleksandrov et al. [41] demonstrated that the F508del revertant I539T and four proline residues at key positions within NBD1 (S422P, S434P, S492P and A534P) were responsible for rescuing the processing, plasma membrane stability and function of human CFTR.
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ABCC7 p.Ser434Pro 26517912:120:263
status: NEW