ABCC7 p.Glu838Ala
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PMID: 23060444
[PubMed]
Wang G et al: "Regulation of Activation and Processing of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by a Complex Electrostatic Interaction between the Regulatory Domain and Cytoplasmic Loop 3."
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Sentence
Comment
11
First, not only D835A, D836A and E838A but also K946A reduced the PKA dependent CFTR activation.
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ABCC7 p.Glu838Ala 23060444:11:33
status: NEW60 Similar observations with D835A and E838A were summarized in Fig. 2D. The K1/2 for PKA activation reduced from 10 units/ml to 5 units/ml once K946 from the CL3, and D835, D836 and E838 from NEG2 were mutated to alanines (Fig.2D).
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ABCC7 p.Glu838Ala 23060444:60:36
status: NEW138 First, the PKA sensitivity of channel activation was significantly enhanced for K946A, D835A, D836A and E838A mutants (Fig.2).
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ABCC7 p.Glu838Ala 23060444:138:104
status: NEW9 First, not only D835A, D836A, and E838A but also K946A reduced the PKA-dependent CFTR activation.
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ABCC7 p.Glu838Ala 23060444:9:34
status: NEW63 Similar observations with D835A and E838A are summarized in Fig. 2D.
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ABCC7 p.Glu838Ala 23060444:63:36
status: NEW167 First, the PKA sensitivity of channel activation was significantly enhanced for K946A, D835A, D836A, and E838A mutants (Fig. 2).
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ABCC7 p.Glu838Ala 23060444:167:105
status: NEW