ABCC4 p.Ala600Pro
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PMID: 14722114
[PubMed]
Koike K et al: "Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions."
No.
Sentence
Comment
58
Position MRP1 MRP3 MRP2 MRP6 SUR1 SUR2 MRP7 MRP4 MRP5 CFTR MSD2 323 Pro Ser Met Ser Gly Gly Arg Lys Thr Trp 343 Pro Pro Pro Pro Pro Asn Pro Pro Pro Pro 359 Pro Pro Tyr Pro Phe Phe Pro Ala Asn Glu 448 Pro Pro Val Leu Pro Pro Pro Pro Pro Pro 464 Pro Pro Pro Pro Val Ser Val Ile Pro Ala 478 Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 557 Pro Pro Pro Thr Pro Pro Pro Ser Val Gly 595 Pro Pro Pro Ala Pro Pro Pro Thr Ala Ala 600 Pro Pro Pro Pro Ser Phe Pro Phe Pro Phe MSD3 1003 Pro Ala Ser Pro Ala Lys Gln Gly Gln 1060 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 1068 Pro Pro Pro Pro Pro Pro Pro Pro Pro Lys 1088 Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro 1113 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 1120 Pro Leu Ile Leu Leu Leu Pro Val Gly Val 1121 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 1150 Pro Pro Pro Ser Pro Pro Pro Pro Pro Pro 1191 Pro Pro Ser Pro Phe Phe Ala Leu Leu Leu AGC AGC-3Ј; and MSD3 Pro mutants B P1003A, 5Ј-C TGG ACT GAT GAC GCC ATC GTC AAC GGG-3Ј; P1060A, 5Ј-C CTG CGG TCA GCC ATG AGC TTC-3Ј; P1068A, 5Ј-C TTT GAG CGG ACC GCG AGT GGG AAC C-3Ј; P1088A, 5Ј-C TCC ATG ATC GCG GAG GTC ATC-3Ј; P1113A, 5Ј-CTG CTG GCC ACG GCC ATC GCC GCC-3Ј; P1120A, 5Ј-GCC ATC ATC ATC GCG CCC CTT GG-3Ј; P1121A, 5Ј-C ATC ATC ATC CCG GCG CTT GGC CTC ATC-3Ј; P1150A, 5Ј-G GTC AGC CGC TCC GCG GTC TAT TCC C-3Ј; P1191A, 5Ј-C CAG AAG GCC TAT TAC GCT AGC ATC GTG GCC AAC-3Ј; P1120A/P1121A, 5Ј-C GCC ATC ATC ATC GCA GCG CTT GGC CTC ATC TAC TTC-3Ј.
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ABCC4 p.Ala600Pro 14722114:58:412
status: NEW