ABCB1 p.Ala58Leu
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PMID: 9287132
[PubMed]
Taguchi Y et al: "Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity."
No.
Sentence
Comment
87
It was reported [21] that no Vbl- or Col-resistant colonies were obtained from cells transfected with either Gly54 -> Val, Ala58 -> Leu, or Gly62 -> Val mutant P-glycoprotein cDNA, and that the major products from these three mutant cDNAs were protein with an apparent mass of 150 kDa when their cDNAs were transiently expressed in HEK 293 cells, suggesting that these mutations in TMl affected the proper folding In this study, we examined whether the substitution of amino acids near His61 in TMl affect substrate specificity of P-glycoprotein.
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ABCB1 p.Ala58Leu 9287132:87:123
status: NEW