ABCB1 p.Thr318Ser
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PMID: 10375401
[PubMed]
Zhou Y et al: "The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2."
No.
Sentence
Comment
66
Those substitutions are T318S, L322I, G324K, S327T, Q330N, V331A, and L332M (Fig. 1).
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ABCB1 p.Thr318Ser 10375401:66:24
status: NEW107 DISCUSSION The Extracellular Loop between TM5 and TM6 Is Essential for UIC2 Recognition In this work, we found that a quadruple substitution of MDR2 residues (T318S, L322I, G324K, and S327T) in the extracellular loop between TM5 and TM6 abolished UIC2 recognition of P-gp.
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ABCB1 p.Thr318Ser 10375401:107:159
status: NEW115 Since the substitutions T318S, L322I, G324K, and S327T had little effect on either MRK-16 labeling or multidrug transporter activity, it is less likely that these mutations produce any major changes in P-gp structure.
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ABCB1 p.Thr318Ser 10375401:115:24
status: NEW106 DISCUSSION The Extracellular Loop between TM5 and TM6 Is Essential for UIC2 Recognition In this work, we found that a quadruple substitution of MDR2 residues (T318S, L322I, G324K, and S327T) in the extracellular loop between TM5 and TM6 abolished UIC2 recognition of P-gp.
X
ABCB1 p.Thr318Ser 10375401:106:159
status: NEW114 Since the substitutions T318S, L322I, G324K, and S327T had little effect on either MRK-16 labeling or multidrug transporter activity, it is less likely that these mutations produce any major changes in P-gp structure.
X
ABCB1 p.Thr318Ser 10375401:114:24
status: NEW