ABCB4 p.Ile299Met
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PMID: 11013259
[PubMed]
Loo TW et al: "Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane."
No.
Sentence
Comment
177
The mutants L210I, K209E, and I214T in TM4 of mouse mdr3 (31) and I299M (48) and L305A, S, or T in TM5 of human P-gp also changed the substrate specificity of the transporter (49).
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ABCB4 p.Ile299Met 11013259:177:66
status: NEW