ABCB1 p.Gly300Val
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PMID: 15530432
[PubMed]
Loo TW et al: "Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein."
No.
Sentence
Comment
59
The processing mutations G300V (TM5) and G722A (TM7) are in TMD1 and TMD2, respectively.
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ABCB1 p.Gly300Val 15530432:59:25
status: NEW70 Although the processing mutations (G251V, G300V, DY490, P709A, G722A, F804A, and P1194A) are located in different segments of P-gp, all the mutants could be rescued when expressed with drug substrates such as cyclosporin A.
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ABCB1 p.Gly300Val 15530432:70:42
status: NEW