ABCB1 p.Ala822Cys

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PMID: 20394729 [PubMed] Loo TW et al: "Human P-glycoprotein is active when the two halves are clamped together in the closed conformation."
No. Sentence Comment
97 Verapamil and rhodamine B were selected for study because thiol-reactive derivatives of these drug substrates have been used extensively in cysteine mutagenesis studies to characterize the X-link 170 kDa + + + _ + ++ + + + T176C D177C D178C L175C T176C D177C D178C L175C N820C + D821C + M1M A822C + ++ + T176C D177C D178C L175C B 0.0003 0.001 0.003 0.009 0.027 0.08 0.24 0.73 [M1M] (mM) X-link 170 kDa 0 2.2 C 0 20 40 60 80 100 PercentCross-linked 0.0003 0.001 0.003 0.009 0.027 0.08 0.24 0.73 [M1M] (mM) 0 2.2 A Fig. 2.
X
ABCB1 p.Ala822Cys 20394729:97:291
status: NEW
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