ABCB1 p.Phe716Ala
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PMID: 22360349
[PubMed]
Mandal D et al: "Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein."
No.
Sentence
Comment
28
The desired nucleotide replacements were confirmed by Big-Dye version 3.1 (BD Sciences) nucleotide sequencing of the MDR1 open reading frame in recombinant plasmids pKM2-MDR1- V715A, -F716A, -I719A, -G723A, -I764A, -I765A, -I768A, -F770A, -L772A, -T837A, -I840A, -I864A, -I867A, -A871F, -T945A, -M948A, -F983A, -M986A, -V988A, -Q990A, and -V991A.
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ABCB1 p.Phe716Ala 22360349:28:184
status: NEW99 As one can see in Figure 2A, none of the substitutions in TM7 (G723A, I719A, F716A, and V715A) or TM8 (L772A, F770A, I768A, I765A, and I764A) was critical for stimulation of [125 I]IAAP binding by cis-(Z)-flupentixol.
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ABCB1 p.Phe716Ala 22360349:99:77
status: NEW