ABCD1 p.Trp326Ala
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PMID: 22703054
[PubMed]
Prasad R et al: "Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance."
No.
Sentence
Comment
1022
Thus, the mutant Trp326Ala remains capable of ATP hydrolysis; however, it does so with a much higher KM value, indicating that the docking of the substrate in the binding pocket has been altered by the mutation.
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ABCD1 p.Trp326Ala 22703054:1022:17
status: NEW1023 The protein, however, appears capable of near-normal drug-transport function in cells expressing the full-length protein carrying the Trp326Ala substitution.
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ABCD1 p.Trp326Ala 22703054:1023:134
status: NEW