ABCC1 p.Asp88Val
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276
Of interest was the demonstration that in a cell line resistant to MTX due to a mutation in the fourth TMD of hRFC (Arg133Leu), the induction of a second mutation in the second TMD (Asp88Val), which alone also impaired function, restored the activity of the carrier and drug sensitivity (Liu and Matherly, 2001).
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ABCC1 p.Asp88Val 14576850:276:182
status: NEW