ABCB3 p.Glu552Ala
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PMID: 17015488
[PubMed]
Sarkadi B et al: "Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system."
No.
Sentence
Comment
466
Interestingly, MDR1/Pgp variants containing combined mutations at the "catalytic carboxylate" and the contralateral signature region (E552A/S1173A) show vanadate-independent retention of ATP, suggesting that a closed formation of the dimer interface (with an occluded ATP) can indeed occur without ATP hydrolysis (374).
X
ABCB3 p.Glu552Ala 17015488:466:134
status: NEW
PMID: 17988154
[PubMed]
Sauna ZE et al: "Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP."
No.
Sentence
Comment
375
with Walker B glutamate mutants of Pgp (E556Q/E1201Q in human and E552A/E1197A in mouse) have characterized the occluded nucleotide conformation (16, 19-22).
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ABCB3 p.Glu552Ala 17988154:375:66
status: NEW