ABCC4 p.Ser1173Ala
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PMID: 17015488
[PubMed]
Sarkadi B et al: "Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system."
No.
Sentence
Comment
466
Interestingly, MDR1/Pgp variants containing combined mutations at the "catalytic carboxylate" and the contralateral signature region (E552A/S1173A) show vanadate-independent retention of ATP, suggesting that a closed formation of the dimer interface (with an occluded ATP) can indeed occur without ATP hydrolysis (374).
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ABCC4 p.Ser1173Ala 17015488:466:140
status: NEW