ABCC5 p.Ala1239Thr
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PMID: 17295059
[PubMed]
Chang XB et al: "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1."
No.
Sentence
Comment
143
Converting the mouse Mrp1 A1239 to human T at the corresponding position (mouse Mrp1/ A1239T) created a protein that increased E217βG transport 3-fold, but decreased resistance to vincristine and VP-16 without affecting anthracycline resistance [85].
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ABCC5 p.Ala1239Thr 17295059:143:86
status: NEW144 Interestingly, substitution of a second murine sequence in Mrp1/ A1239T with a human MRP1 codon to generate the Mrp1/ A1239T/Q1086E double mutant restored the resistance to both vincristine and VP-16 [85].
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ABCC5 p.Ala1239Thr 17295059:144:65
status: NEWX
ABCC5 p.Ala1239Thr 17295059:144:118
status: NEW