ABCC4 p.His35Asp
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331
In this respect, perhaps the best characterized antifolate-resistant cell line with enhanced GGH activity is H35D rat hepatoma cells [205].
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ABCC4 p.His35Asp 17333344:331:109
status: NEW333 H35D cells also exhibited a 90% decrease in the formation of MTX polyglutamates in the absence of alterations in FPGS activity; the parent monoglutamate form of MTX was the predominant intracellular species [206].
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ABCC4 p.His35Asp 17333344:333:0
status: NEW334 Unlike antifolates, the total cellular folate pool was identical in both parental H35 and H35D cells grown in medium containing folic acid concentrations at the range of 2.3-10 μM. Therefore, the impact of enhanced GGH activity on cellular THF cofactor polyglutamates is much less prominent than that on antifolates.
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ABCC4 p.His35Asp 17333344:334:90
status: NEW335 However, the antifolate-resistance phenotype in H35D cells should be regarded as multifactorial since these drug-resistant cells also displayed a marked impairment of antifolate uptake.
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ABCC4 p.His35Asp 17333344:335:48
status: NEW