ABCC4 p.Ser46Asn
[switch to full view]Comments [show]
None has been submitted yet.
No.
Sentence
Comment
186
Consistently, an adjacent Ser46Asn substitution in MTX-resistant mouse leukemia cells grown on leucovorin as the sole folate source, resulted in a dramatic fall in the MTX transport Vmax with a much lesser decrease in the transport Vmax for the naturally occurring folates leucovorin and 5-CH3-THF [128].
X
ABCC4 p.Ser46Asn 17333344:186:26
status: NEW196 Of interest was the finding that some of the well-characterized mutations identified in antifolate-resistant cell lines in vitro including Ser46Asn were also identified in osteosarcoma patients.
X
ABCC4 p.Ser46Asn 17333344:196:139
status: NEW199 In contrast, three mutations, Ser4Pro, Ser46Asn and Gly259Trp complemented the RFC null cell line and conferred only a modest level of MTX resistance. Whereas, several other mutations complemented the RFC null cell line but failed to confer any MTX resistance.
X
ABCC4 p.Ser46Asn 17333344:199:39
status: NEW