ABCC4 p.Gly538Ala
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PMID: 17412754
[PubMed]
Wang Z et al: "Signatures of recent positive selection at the ATP-binding cassette drug transporter superfamily gene loci."
No.
Sentence
Comment
203
Recently, the ABCC11 SNP e5/G538A was found to be a determinant of earwax type, with the G- and A-alleles corresponding to wet and dry earwax types (64).
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ABCC4 p.Gly538Ala 17412754:203:28
status: NEW208 All other HapMap genotyped ABCC11SNPs are monomorphic in the Asian populations (Supplementary Material, Table S2), thus preventing the LRH test from being performed on SNP e5/G538A.
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ABCC4 p.Gly538Ala 17412754:208:175
status: NEW223 The only sole HapMap genotyped, high frequency SNP that did not show evidence of RPS in this study is the ABCC11 SNP e5/G538A.
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ABCC4 p.Gly538Ala 17412754:223:120
status: NEW202 Recently, the ABCC11 SNP e5/G538A was found to be a determinant of earwax type, with the Gand A-alleles corresponding to wet and dry earwax types (64).
X
ABCC4 p.Gly538Ala 17412754:202:28
status: NEW207 All other HapMap genotyped ABCC11SNPs are monomorphic in the Asian populations (Supplementary Material, Table S2), thus preventing the LRH test from being performed on SNP e5/G538A.
X
ABCC4 p.Gly538Ala 17412754:207:175
status: NEW222 The only sole HapMap genotyped, high frequency SNP that did not show evidence of RPS in this study is the ABCC11 SNP e5/G538A.
X
ABCC4 p.Gly538Ala 17412754:222:120
status: NEW
PMID: 18699730
[PubMed]
Kuo MT et al: "Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities."
No.
Sentence
Comment
117
Interestingly, a single-nucleotide polymorphism in MRP8 (G538A) is associated with the dry-earwax phenotype in humans, and GA and GG, with the wet type (286) and colostrum and cerumen section (177).
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ABCC4 p.Gly538Ala 18699730:117:57
status: NEW