ABCMdb

ABCC11 p.Ala473Cys

None has been submitted yet.

Publications

PMID: 17412754 [PubMed] Wang Z et al: "Signatures of recent positive selection at the ATP-binding cassette drug transporter superfamily gene loci."

No. Sentence Comment

66 Hence, a total of 32 SNPs were found to display RPS, most of them being selected only in a single population except for SNPs e35/T5562C in ABCA2, e21/G2677T/A in ABCB1, e9/C504T in ABCB4 and i1/T1541G and i14/A473C in ABCC11, which showed RPS in two populations (Table 2). Login to comment
71 Interestingly, the major T and A alleles of SNPs i1/T1541G and i14/A473C, respectively, in ABCC11 that showed RPS in both the YRI and CEU (Table 2) were found to be fixed in the CHB and JPT (Supplementary Material, Table S2). Login to comment
96 Ala rs497692 G - - LRH - 0.55 0.95 1.25 ABCC1 50 FR/G-260C 50 FR - rs504348 G - - LRH - - - - ABCC2 E1/C-24T Exon 1 - rs717620 T - - LRH - 20.54 2 1.14 21.46 E10/G1249A Exon 10 Val/Ile rs2273697 A - - LRH - 20.20 2 1.67 -1.32 I19/C-2133T Intron 19 - rs2002042 T - - - LRH 20.80 1.02 2 1.36 I23/G-752A Intron 23 - rs7898096 A - - - MTC - - 2 1.36 E25/G3542T Exon 25 Arg/Leu rs8187692 T - - - MTC 0.22 - 2 2.64 I26/T154C Intron 26 - rs3758395 C LRH - - - 2 1.24 20.57 20.36 I29/A154G Intron 29 - rs3740065 G LRH - - - 2.09 - 0.24 ABCC3 I1/C-3695G Intron 1 - rs719717 C MTC - - - 1.81 0.36 0.52 I30/A-1022C Intron 30 - rs3785911 C MTC - - - 0.96 0.71 0.29 ABCC4 I4/C4542Tc Intron 4 - rs17189481 T - - LRH - - - - ABCC5 I17/T20G Intron 17 - rs4148584 G LRH - - - 2 1.59 20.59 0.83 ABCC6 I30/A-31G Intron 30 - rs212097 A - - LRH - 0.76 0.17 1.02 ABCC7 I10/G377T Intron 10 - rs10487371 T - - - MTC - - 2 3.43 ABCC8 I16/A2575G Intron 16 - rs2237984 G MTC - - - 2.07 1.44 0.27 ABCC9 I27/C-1020G Intron 27 - rs704176 C - - - MTC 0.39 0.09 2.51 I37/C533G Intron 37 - rs829060 C - - - MTC 20.63 20.16 2 2.68 ABCC10 I1/G7A Intron 1 - rs9394952 A MTC - - - 0.90 1.24 1.19 ABCC11 I1/T1541G Intron 1 - rs13332304 T - - LRH LRH - - - I14/A473C Intron14 - rs7206909 A - - LRH LRH - 0.91 1.15 E19/C2436T Exon 19 Phe/Phe rs11866251 C - - MTC - - 1.37 1.15 I23/T-570C Intron 23 - rs11861031 T - - - LRH - 0.54 1.05 ABCC12 I2/C759A Intron 2 - rs8049005 C - - LRH - - 1.19 - ABCC13 50 FR/A-59G 50 FR - rs2822520 G LRH - - - 2 0.36 22.14 20.18 I1/A953C Intron 1 - rs2822522 C LRH - - - 2 1.21 20.90 21.04 ABCG2 E5/C421A Exon 5 Gln/Lys rs2231142 A MTC - - - 2 1.34 20.08 - a LRH represents SNPs that passed the modified long-range-haplotype test only if not corrected for multiple testing; MTC represents SNPs that passed both the modified LRH test and subsequent multiple test correction. Login to comment
68 Hence, a total of 32 SNPs were found to display RPS, most of them being selected only in a single population except for SNPs e35/T5562C in ABCA2, e21/G2677T/A in ABCB1, e9/C504T in ABCB4 and i1/T1541G and i14/A473C in ABCC11, which showed RPS in two populations (Table 2). Login to comment
73 Interestingly, the major T and A alleles of SNPs i1/T1541G and i14/A473C, respectively, in ABCC11 that showed RPS in both the YRI and CEU (Table 2) were found to be fixed in the CHB and JPT (Supplementary Material, Table S2). Login to comment