ABCC4 p.Leu1084Lys
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PMID: 15083066
[PubMed]
Lee YM et al: "Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)."
No.
Sentence
Comment
204
For example, induced mutations in rat Mrp2 resulted in acquired transport activity of Mrp2 for taurocholate, whereas mutation of the corresponding position in Mrp3 (Mrp3- Leu1084 Lys) resulted in loss of transport activity of Mrp3 for taurocholate and glucuronoside conjugates [41].
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ABCC4 p.Leu1084Lys 15083066:204:171
status: NEW
PMID: 16815813
[PubMed]
Choudhuri S et al: "Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters."
No.
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496
Using site-directed mutagenesis, Ito et al. (2001d) showed that in rat Mrp3, substitution of Leu1084 with Lys (L1084K), but not with Val or Met, resulted in the loss of transport activity for taurocholate and glucuronide conjugates.
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ABCC4 p.Leu1084Lys 16815813:496:93
status: NEWX
ABCC4 p.Leu1084Lys 16815813:496:111
status: NEW