ABCC2 p.Ile448Val
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PMID: 10978330
[PubMed]
Ryu S et al: "Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2."
No.
Sentence
Comment
41
For mutagenesis, we constructed pCI-neo/ MRP2X, which contains a deletion of XhoI site in the multicloning site of pCI-neo, and pCI-neo/MRP2V, which contains I448V and L653V mutations by overlapping polymerase chain reaction mutagenesis method to create Sse8387I and MluI sites, respectively.
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ABCC2 p.Ile448Val 10978330:41:158
status: NEW113 GS-MF Excretion of Mutant MRP2 Proteins-First of all, we examined the excretion of GS-MF from COS-7 cells transfected with pCI-neo/MRP2V, which contains conservative amino acid changes as I448V and L653V, or pCI-neo/MRP2X, which contains a small deletion at the multi-cloning site of the vector.
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ABCC2 p.Ile448Val 10978330:113:188
status: NEW144 pCI-neo/MRP2V contains mutations of I448V and L653V, which were located in TM8 and NBD1, respectively. In patients with Dubin-Johnson syndrome, loss of function mutations was occasionally found in NBD1 (12).
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ABCC2 p.Ile448Val 10978330:144:36
status: NEW