ABCC2 p.Lys1544Ala
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PMID: 11274200
[PubMed]
Harris MJ et al: "Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT)."
No.
Sentence
Comment
97
The T1543A and K1544A mutants had both apical and basolateral targeting (nonpolarized distribution) with an increase in protein accumulation in intracellular vesicles.
X
ABCC2 p.Lys1544Ala 11274200:97:15
status: NEW112 B, the K1544A mutation also lost polarized distribution of the protein with the protein detected in the apical and basolateral membranes.
X
ABCC2 p.Lys1544Ala 11274200:112:7
status: NEW166 The canonical PDZ domain is reported to tolerate any residue (X) at the -1 position, but the K1544A caused nonpolarized targeting, suggesting some flexibility in the constraints determining functional PDZ domains.
X
ABCC2 p.Lys1544Ala 11274200:166:93
status: NEW