ABCMdb

ABCB2 p.Gly34Ala

None has been submitted yet.

Publications

PMID: 15801936 [PubMed] Zhou Q et al: "Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer."

No. Sentence Comment

113 Of the nine SNPs analyzed for the ABCG2 gene, variant genotypes Figure 2 Genotype-phenotype associations 1800 1500 1200 900 600 300 0 C max (mg/L) CC CT + TT ABCB1 C3435T Genotype P = 0.047 CPT-11 1200 900 600 300 0 C max (mg/L) CC-GG-CC CT-GT-CT TT-TT-TT ABCB1 Haplotype P = 0.055 SN-38G 1500 1200 900 600 300 0 C max (ng/ml) GG GA + AA ABCB2 G34A Genotype P = 0.056 CPT-11 400 300 200 100 0 AUC 0Æ• (ng*h/ml) CTCA H + delCTCA ABCG2-19572-19569 CTCAdel Genotype P = 0.068 SN-38 0.1 0.12 0.08 0.06 0.02 0.04 0 REC CTCA H + delCTCA ABCG2-19572-19569 CTCAdel Genotype P = 0.019 SN-38G A B C E D were only found for the -19572-19569delCTCA, G34A and C421A SNPs. Login to comment
115 Patients who were wild type for the G34A SNP at exon 2 showed a trend towards lower systemic exposures to irinotecan (i.e. Cmax) compared with patients with one or two variant alleles (Figure 2C, P = 0.056). Login to comment