ABCMdb

ABCC4 p.Ala134Ser

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Publications

PMID: 19696793 [PubMed] Low SK et al: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients."

No. Sentence Comment

56 In this study, we examined a total of 141 SNPs and two gene deletions in 13 candidate genes that were considered to be involved in the activation (CYP2B6, CYP2C9, Table 2 Continued MAF Cochran-Armitage HWE CHR Gene SNP Allele1 Allele2 Position/effect ADR Non-ADR trend P-value ADR Non-ADR 13 rs9590216 T C Intron 1 0.45 0.46 0.93 0.24 0.11 13 rs9561820 T C Intron 1 0.31 0.29 0.63 0.17 0.010 13 rs4148431 A G Intron 1 0.44 0.45 0.84 0.48 0.023 13 rs7328332 T C Intron 1 0.14 0.10 0.23 1.00 1.00 13 rs870004 A G Intron 1 0.18 0.26 0.063 0.69 0.65 13 rs8001475 C T Intron 1 0.29 0.35 0.24 0.78 0.45 13 rs4148426 G C Intron 1 0.18 0.25 0.11 0.68 0.34 13 rs9524873 A G Intron 1 0.26 0.22 0.40 0.25 0.010 13 rs4771910 C T Intron 1 0.30 0.35 0.40 0.58 0.70 13 rs10508017 T C Intron 1 0.24 0.23 0.83 0.34 0.025 13 rs4148424 T C Intron 1 0.34 0.36 0.56 0.61 1.00 13 rs4148422 C T Intron 1 0.37 0.36 0.92 0.80 0.26 13 rs34665760 A G Intron 1 0.24 0.30 0.21 0.75 0.84 13 rs4773872 T C Intron 1 0.28 0.36 0.084 0.40 0.57 13 rs4771912 G A Intron 1 0.24 0.33 0.045 1.00 0.33 13 rs4773875 T G Intron 1 0.43 0.35 0.10 0.34 0.70 13 rs8001444 T C Intron 1 0.37 0.47 0.041 0.80 1.00 17 ALDH3A1 rs758427 T C 5' near gene 0.49 0.49 0.88 0.82 0.73 17 rs11657205 T C 5' near gene 0.49 0.48 0.82 1.00 0.49 17 rs11204411 C T 5' near gene 0.20 0.22 0.67 1.00 0.45 17 rs57555435 A G Exon 10 syn. 0.14 0.14 0.85 0.34 0.040 17 rs2228100 G C Ala329Pro 0.32 0.33 0.82 1.00 0.85 17 rs3744692 A G Glu309Gly 0.03 0.05 0.36 1.00 1.00 17 rs2072330 A T Exon 6 syn. 0.45 0.44 0.83 0.64 0.06 17 rs887241 T G Ala134Ser 0.03 0.04 0.73 1.00 1.00 19 CYP2B6 rs7254579 C T 5' near gene 0.46 0.49 0.57 0.24 0.24 19 rs4802101 T C 5' near gene 0.39 0.32 0.17 0.81 0.56 19 rs4803415 T C Intron 1 0.23 0.19 0.35 0.52 0.28 19 rs4803419 T C Intron 3 0.45 0.49 0.49 0.64 0.61 19 rs3745274 T G His172Gln 0.13 0.17 0.32 1.00 1.00 19 rs2279343 G A Arg262Lys 0.16 0.22 0.13 1.00 0.81 19 rs2279345 T C Intron 5 0.36 0.31 0.28 1.00 0.32 19 rs7255374 T C Intron 8 0.19 0.22 0.51 1.00 0.80 19 rs1042389 C T 3' UTR 0.30 0.26 0.46 0.09 0.83 GSTM1 and GSTT1 deletion ADR Non-ADR Gene Deletion Wildtype Deletion Wildtype Fisher`s exact P-value Odds ratio GSTM deletion 46 51 102 87 0.32 0.769 GSTT deletion 41 56 83 108 0.90 0.953 Abbreviations: ADR, adverse drug reaction; HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency. Login to comment