ABCB1 p.Arg588Leu
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PMID: 20082599
[PubMed]
Jemnitz K et al: "ABCC2/Abcc2: a multispecific transporter with dominant excretory functions."
No.
Sentence
Comment
107
Moreover, several mutations in the rat Abcc2 were shown to affect substrate specificity (Ito et al., 2001b), with D329N and R588L being the most striking, as these mutations did not significantly modulate the transport of taurolitocholate-sulfate and E3040-glucuronide, whereas these changes inhibited the efflux of DNP-SG and LTC4.
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ABCB1 p.Arg588Leu 20082599:107:124
status: NEW