ABCB2 p.Gly183Asp

[switch to full view]
Comments [show]
Publications
PMID: 9521654 [PubMed] Kwan T et al: "Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains."
No. Sentence Comment
191 Group 2 comprised 19 mutants with intermediate phenotypes: Q128H, A136V, Q139H, Q139P, Q139R, E155G, E155K, S176P, K177I, E180G, G183D, D184N, A192T, F200L, F204S, R206L, L210I, T211P, and V213A; these were found throughout the mutagenized segment, with a cluster at the C-terminal portion of IC1.
X
ABCB2 p.Gly183Asp 9521654:191:129
status: NEW
Login to comment

194 Such mutants showed near wild-type transport Table 1: Summary of Mutations Identifieda TM2 IC1 TM3 EC2 TM4 Q128H R138H F159I S176P G187E R206L L210I Q128R Q139H V161E K177I A192T W208G T211P L134P Q139P H162R N179S F200L K209E V213A A136V Q139R T169I E180G F204S I214L Q145H R170L G181R I214T F147L L171P G183D S224P F148S T172P D184N E155G D174G E155K S176F a Summary of the mutations identified in the current screen together with their position within the predicted secondary structure of P-glycoprotein, with respect to the second (TM2), third (TM3), and fourth (TM4) predicted transmembrane domains together with the first intracellular (IC1) and second extracellular loop (EC2).
X
ABCB2 p.Gly183Asp 9521654:194:305
status: NEW
Login to comment