ABCC4 p.Glu1202Ala
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PMID: 14596601
[PubMed]
Carrier I et al: "Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein."
No.
Sentence
Comment
234
Indeed, they suggest that the single E556A/Q and E1202A/Q mutants are defective in the second ATP hydrolysis event of the catalytic cycle, which should reset the protein after hydrolysis at the first site.
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ABCC4 p.Glu1202Ala 14596601:234:49
status: NEW