ABCB2 p.Ser142Ala
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PMID: 15322097
[PubMed]
Chen M et al: "Functional non-equivalence of ATP-binding cassette signature motifs in the transporter associated with antigen processing (TAP)."
No.
Sentence
Comment
222
The S142A mutant hydrolyzes ATP with 50% of the activity of wild type GlcV.
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ABCB2 p.Ser142Ala 15322097:222:4
status: NEW233 The introduction of an alanine at this position seems to strengthen the NBD dimer affinity, because, in contrast to wild type GlcV, transient GlcV dimers of S142A mutants could be detected by gel filtration in the presence of MgATP (38).
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ABCB2 p.Ser142Ala 15322097:233:157
status: NEW223 The S142A mutant hydrolyzes ATP with 50% of the activity of wild type GlcV.
X
ABCB2 p.Ser142Ala 15322097:223:4
status: NEW234 The introduction of an alanine at this position seems to strengthen the NBD dimer affinity, because, in contrast to wild type GlcV, transient GlcV dimers of S142A mutants could be detected by gel filtration in the presence of MgATP (38).
X
ABCB2 p.Ser142Ala 15322097:234:157
status: NEW