ABCMdb

ABCC1 p.Glu631Gln

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Publications

PMID: 18249138 [PubMed] Hazai E et al: "Homology modeling of breast cancer resistance protein (ABCG2)."

No. Sentence Comment

97 Table 1 Sequence identity and similarity between BCRP and available templates PDB ID Title Identity Similarity Ligand Nucleotide binding domain 1Q1B Crystal structure of E. coli MalK in the nucleotide-free form 31.00 51.00 No 1Q12 Crystal structure of the ATP-bound E. coli MalK 31.00 51.00 ATP 1OXS Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 28.00 49.00 I- 1MV5 Crystal structure of LmrA ATP-binding domain 28.00 50.00 ATP/ADP 2FF7 The ABC-ATPase of the ABC-transporter HlyB in the ADP bound state 29.00 50.00 ADP 1MT0 ATP-binding domain of haemolysin B from E. coli 29.00 49.00 Sulphate 1OXX Crystal structure of GlcV, the ABC-ATPase of the glucose ABC transporter from Sulfolobus solfataricus 27.00 49.00 I- 1L2T Dimeric structure of MJ0796, a bacterial ABC transporter cassette 27.00 50.00 ATP/isopropanol 2FGK Crystal structure of the ABC-cassette E631Q mutant of HlyB with bound ATP 29.00 49.00 ATP 1XEF Crystal structure of the ATP/Mg2+ bound composite dimer of HlyB-NBD 29.00 49.00 ATP 1G29 Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter 26.00 46.00 Pyrophosphate/ dioxane 1B0U ATP-binding subunit of the histidine permease from Salmonella Typhimurium 25.00 52.00 ATP 1G6H Crystal structure of the ADP conformation of Mj1267 22.00 43.00 ADP 1R0W Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo 24.00 42.00 Acetic acid 1JJ7 Crystal structure of the C-terminal ATPase domain of human TAP1 25.00 44.00 ADP 2HYD Multidrug ABC transporter SAV1866 28.00 49.00 ADP 2CBZ Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 19.20 32.40 ATP The templates selected for modeling BCRP structure are indicated in bold. Login to comment

PMID: 16864587 [PubMed] Ernst R et al: "Engineering ATPase activity in the isolated ABC cassette of human TAP1."

No. Sentence Comment

43 For the NBD of HlyB, a mutation of the corresponding histidine to alanine (H662A) eliminated ATPase activity as well, whereas residual ATPase activity was detected in the glutamate to glutamine mutant (E631Q) (30). Login to comment