ABCA1 p.Thr1242Asp
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PMID: 15218032
[PubMed]
Roosbeek S et al: "Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter."
No.
Sentence
Comment
94
Similar measurements were performed in the presence of 50 M 4,5,6,7-tetrabromobenzotriazole and apigenin CK2 inhibitors on Mock-transfected and Hek-293 cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, and T1242D/T1243D ABCA1 mutants.
X
ABCA1 p.Thr1242Asp 15218032:94:240
status: NEW134 Mutants were also designed to mimic phosphorylated residues as T1242D, T1243D, T1242D/T1243D.
X
ABCA1 p.Thr1242Asp 15218032:134:63
status: NEWX
ABCA1 p.Thr1242Asp 15218032:134:79
status: NEW162 The effect of the specific CK2 inhibitors 4,5,6,7-tetrabromo- benzotriazole and apigenin on the flippase activity in Hek-293 Tet-Off cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, S1255A, and T1242D/ T1243D mutants was consistent with the above data.
X
ABCA1 p.Thr1242Asp 15218032:162:221
status: NEW177 This increase was more pronounced for the T1243A mutation either alone or in combination with the T1242A mutation, whereas the effect of the T1242A and S1255A mutants was similar.
X
ABCA1 p.Thr1242Asp 15218032:177:4
status: NEWX
ABCA1 p.Thr1242Asp 15218032:177:20
status: NEW179 The T1242D, T1243D, T1242D/T1243D mutations, which mimic CK2 phosphorylation, had an opposite effect to the Thr-Ala mutations, as apoprotein binding to cells transfected with these mutants amounted to around 110% of WT ABCA1.
X
ABCA1 p.Thr1242Asp 15218032:179:4
status: NEWX
ABCA1 p.Thr1242Asp 15218032:179:20
status: NEW197 The T1242D, T1243D, and T1242/ T1243D mutations had an opposite effect as the efflux induced by that mutant was close to WT ABCA1.
X
ABCA1 p.Thr1242Asp 15218032:197:4
status: NEW92 Similar measurements were performed in the presence of 50 òe;M 4,5,6,7-tetrabromobenzotriazole and apigenin CK2 inhibitors on Mock-transfected and Hek-293 cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, and T1242D/T1243D ABCA1 mutants.
X
ABCA1 p.Thr1242Asp 15218032:92:239
status: NEW132 Mutants were also designed to mimic phosphorylated residues as T1242D, T1243D, T1242D/T1243D.
X
ABCA1 p.Thr1242Asp 15218032:132:63
status: NEWX
ABCA1 p.Thr1242Asp 15218032:132:79
status: NEW160 The effect of the specific CK2 inhibitors 4,5,6,7-tetrabromo- benzotriazole and apigenin on the flippase activity in Hek-293 Tet-Off cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, S1255A, and T1242D/ T1243D mutants was consistent with the above data.
X
ABCA1 p.Thr1242Asp 15218032:160:221
status: NEW195 The T1242D, T1243D, and T1242/ T1243D mutations had an opposite effect as the efflux induced by that mutant was close to WT ABCA1.
X
ABCA1 p.Thr1242Asp 15218032:195:4
status: NEW