ABCMdb

ABCA1 p.Thr1243Asp

None has been submitted yet.

Publications

PMID: 15218032 [PubMed] Roosbeek S et al: "Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter."

No. Sentence Comment

94 Similar measurements were performed in the presence of 50 ␮M 4,5,6,7-tetrabromobenzotriazole and apigenin CK2 inhibitors on Mock-transfected and Hek-293 cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, and T1242D/T1243D ABCA1 mutants. Login to comment
134 Mutants were also designed to mimic phosphorylated residues as T1242D, T1243D, T1242D/T1243D. Login to comment
162 The effect of the specific CK2 inhibitors 4,5,6,7-tetrabromo- benzotriazole and apigenin on the flippase activity in Hek-293 Tet-Off cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, S1255A, and T1242D/ T1243D mutants was consistent with the above data. Login to comment
177 This increase was more pronounced for the T1243A mutation either alone or in combination with the T1242A mutation, whereas the effect of the T1242A and S1255A mutants was similar. Login to comment
179 The T1242D, T1243D, T1242D/T1243D mutations, which mimic CK2 phosphorylation, had an opposite effect to the Thr-Ala mutations, as apoprotein binding to cells transfected with these mutants amounted to around 110% of WT ABCA1. Login to comment
197 The T1242D, T1243D, and T1242/ T1243D mutations had an opposite effect as the efflux induced by that mutant was close to WT ABCA1. Login to comment
92 Similar measurements were performed in the presence of 50 òe;M 4,5,6,7-tetrabromobenzotriazole and apigenin CK2 inhibitors on Mock-transfected and Hek-293 cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, and T1242D/T1243D ABCA1 mutants. Login to comment
132 Mutants were also designed to mimic phosphorylated residues as T1242D, T1243D, T1242D/T1243D. Login to comment
160 The effect of the specific CK2 inhibitors 4,5,6,7-tetrabromo- benzotriazole and apigenin on the flippase activity in Hek-293 Tet-Off cells transfected with WT ABCA1 and with the T1242A, T1243A, T1242A/T1243A, S1255A, and T1242D/ T1243D mutants was consistent with the above data. Login to comment
195 The T1242D, T1243D, and T1242/ T1243D mutations had an opposite effect as the efflux induced by that mutant was close to WT ABCA1. Login to comment