ABCMdb

ABCA1 p.Cys1465Ser

None has been submitted yet.

Publications

PMID: 19258317 [PubMed] Hozoji M et al: "Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1."

No. Sentence Comment

124 TABLE 1 Cysteine mutants of ABCA1 Protein ApoA-I binding Cholesterol efflux Mutations Wild type ϩ ϩ None C1S ϩ ϩ C54S C2S - - C75S C3S ϩ ϩ C81S C4S ϩ ϩ C195S C5S ϩ ϩ C215S C6S - - C309S C7S ϩ ϩ C355S C8S ϩ ϩ C504S C9S ϩ ϩ C626S C10S ϩ ϩ C791S C11S ϩ ϩ C1418S C12S ϩ ϩ C1429S C13S ϩ ϩ C1463S C14S ϩ ϩ C1465S C15S ϩ - C1477S C16S ϩ ϩ C1814S C2/6S - - C75S/C309S C11/12S ϩ ϩ C1418S/C1429S C13/14S - - C1463S/C1465S C13/14/15S - - C1463S/C1465S/C1477S C11/12/13/14S - - C1418S/C1429S/C1463S/C1465S C11/12/13/15S - - C1418S/C1429S/C1463S/C1477S C11/12/14/15S - - C1418S/C1429S/C1465S/C1477S C11/13/14/15S - - C1418S/C1463S/C1465S/C1477S C12/13/14/15S - - C1429S/C1463S/C1465S/C1477S C11/12/13/14/15S - - C1418S/C1429S/C1463S/C1465S/C1477S C2/6/13/14/15S - - C75S/C309S/C1463S/C1465S/C1477S Cys4#1 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1465S/1814S Cys4#2 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1463S/1814S Cys5 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1814S irreversibly abolished apoA-I binding to cells expressing ABCA1(Cys5)-GFP (supplemental Fig. 4). Login to comment
122 TABLE 1 Cysteine mutants of ABCA1 Protein ApoA-I binding Cholesterol efflux Mutations Wild type af9; af9; None C1S af9; af9; C54S C2S afa; afa; C75S C3S af9; af9; C81S C4S af9; af9; C195S C5S af9; af9; C215S C6S afa; afa; C309S C7S af9; af9; C355S C8S af9; af9; C504S C9S af9; af9; C626S C10S af9; af9; C791S C11S af9; af9; C1418S C12S af9; af9; C1429S C13S af9; af9; C1463S C14S af9; af9; C1465S C15S af9; afa; C1477S C16S af9; af9; C1814S C2/6S afa; afa; C75S/C309S C11/12S af9; af9; C1418S/C1429S C13/14S afa; afa; C1463S/C1465S C13/14/15S afa; afa; C1463S/C1465S/C1477S C11/12/13/14S afa; afa; C1418S/C1429S/C1463S/C1465S C11/12/13/15S afa; afa; C1418S/C1429S/C1463S/C1477S C11/12/14/15S afa; afa; C1418S/C1429S/C1465S/C1477S C11/13/14/15S afa; afa; C1418S/C1463S/C1465S/C1477S C12/13/14/15S afa; afa; C1429S/C1463S/C1465S/C1477S C11/12/13/14/15S afa; afa; C1418S/C1429S/C1463S/C1465S/C1477S C2/6/13/14/15S afa; afa; C75S/C309S/C1463S/C1465S/C1477S Cys4#1 af9; af9; C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1465S/1814S Cys4#2 af9; af9; C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1463S/1814S Cys5 af9; af9; C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1814S Two Intramolecular Disulfide Bonds in ABCA1 APRIL 24, 2009ߦVOLUME 284ߦNUMBER 17 JOURNAL OF BIOLOGICAL CHEMISTRY 11297 irreversibly abolished apoA-I binding to cells expressing ABCA1(Cys5)-GFP (supplemental Fig. 4). Login to comment