ABCA1 p.Leu317Ala
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PMID: 19451134
[PubMed]
Futter M et al: "Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors."
No.
Sentence
Comment
130
To determine whether any of these NR binding motifs could mediate the interaction between huntingtin and the LXR LBD, we made a series of leucine to alanine point mutations (L211A, L297A, L317A and L326A).
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ABCA1 p.Leu317Ala 19451134:130:188
status: NEW155 (A) Immunoprecipitation of Myc-tagged LXR and (B) activity of an LXRE-luciferase reporter expressed in SK-N-SH cells or HEK cells, respectively, in combination with individual Leu to Ala FLAG-huntingtin 1-588 mutants (L211A, L297A, L317A, L326A), a mutant with all five NR binding motifs mutated (quadruple) or a deletion mutant missing the region containing the five motifs (deletion).
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ABCA1 p.Leu317Ala 19451134:155:232
status: NEW