ABCB6 p.Cys26Ser
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PMID: 21199866
[PubMed]
Fukuda Y et al: "Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8."
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Comment
142
Therefore, we next determined whether ABCB6 engineered to contain free thiols in the ER was ER-retained by generating the ABCB6 mutants C26A and C26S as well the mutants lacking both cysteine residues, C8S/C26S.
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ABCB6 p.Cys26Ser 21199866:142:145
status: NEWX
ABCB6 p.Cys26Ser 21199866:142:206
status: NEW200 The ER retention and instability of ABCB6-C8S, -C26S, and -C8S/C26S suggests that these residues have a crucial role in the folding of the ABCB6 amino terminus, a domain that appears to be important in determining the stability of ABCB6.
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ABCB6 p.Cys26Ser 21199866:200:48
status: NEWX
ABCB6 p.Cys26Ser 21199866:200:63
status: NEW