ABCC1 p.Tyr1189Phe
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PMID: 15652236
[PubMed]
Conseil G et al: "Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas."
No.
Sentence
Comment
125
More conservatively substituted Y1189F and Y1189W mutant proteins were generated and these also exhibited levels of transport activity that were reduced by a similar extent (data not shown).
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ABCC1 p.Tyr1189Phe 15652236:125:32
status: NEW213 Conservatively substituted mutants Y1189F and Y1189Walso showed a comparable reduction in transport activity (not shown), suggesting that physical properties in addition to the aromaticity of Tyr1189 and Tyr1190 are important for their role in MRP1 transport activity.
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ABCC1 p.Tyr1189Phe 15652236:213:35
status: NEW212 Conservatively substituted mutants Y1189F and Y1189Walso showed a comparable reduction in transport activity (not shown), suggesting that physical properties in addition to the aromaticity of Tyr1189 and Tyr1190 are important for their role in MRP1 transport activity.
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ABCC1 p.Tyr1189Phe 15652236:212:35
status: NEW