ABCC8 p.Gln1426Ala
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PMID: 12169627
[PubMed]
Matsuo M et al: "Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding."
No.
Sentence
Comment
101
In contrast, the equivalent mutations in NBD2 (Q1426A and H1537A) did not affect functional expression.
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ABCC8 p.Gln1426Ala 12169627:101:47
status: NEW104 However, both the Q1426A and H1537A mutations reduced the ability of 100 mM MgADP to stimulate channel activity, resulting in a 50 T 5.2% (n = 5) block of Kir6.2/SUR1-Q1426A currents and a 30 T 2.6% (n = 11) block of Kir6.2/SUR1-H1537A currents (Figure 5).
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ABCC8 p.Gln1426Ala 12169627:104:18
status: NEWX
ABCC8 p.Gln1426Ala 12169627:104:167
status: NEW122 Mean KATP conductance recorded from patches excised from oocytes co-expressing Kir6.2 and either wild-type SUR1 or SUR containing mutations in the linker of NBD2 (SUR1-Q1426A and SUR1-H1537A).
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ABCC8 p.Gln1426Ala 12169627:122:168
status: NEW239 Mutations in the NBD2 linker were: SUR1-S1482R and SUR2-S1446R (S2R); SUR1-Q1426A, SUR1-H1537A.
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ABCC8 p.Gln1426Ala 12169627:239:75
status: NEW