ABCC8 p.Ala286Cys
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PMID: 18996847
[PubMed]
Garneau L et al: "Hydrophobic interactions as key determinants to the KCa3.1 channel closed configuration. An analysis of KCa3.1 mutants constitutively active in zero Ca2+."
No.
Sentence
Comment
305
In addition, although binding of MTSETϩ to Cys engineered at 286 led to channels with an increased sensitivity to Ca2ϩ , neither the A286C nor the A286C mutants modified by MTSETϩ showed constitutive activity as shown previously (13).
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ABCC8 p.Ala286Cys 18996847:305:145
status: NEWX
ABCC8 p.Ala286Cys 18996847:305:159
status: NEW378 These additional gating mechanisms might explain Po values of the order of 0.2 at saturating Ca2ϩ concentrations (beta1 Ͼ ␣1) reported for the wild type KCa3.1 (46) as well as the drastic Po increase of the A283C and A286C mutants following binding of MTSEAϩ (13, 20).
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ABCC8 p.Ala286Cys 18996847:378:236
status: NEW