ABCMdb

ABCC8 p.Ala1166Cys

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Publications

PMID: 20099993 [PubMed] Bai JP et al: "Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors."

No. Sentence Comment

65 (continued) Risk Factors ACE (rs4340) D/D (+) (RR 5.28, 95% CI 2.48-11.24, p<0.0001) AGT (rs5051) (-), AGTR1 (rs5186) (-) TGF-beta protein expression significantly higher in those with acute cyclosporine toxicity than those with acute rejection or chronic allograft nephropathy (p<0.05) Tissue factor expression (+) (p=0.0026 for 18 transplant recipients with cyclosporine nephrotoxicity vs 6 patients with normal kidneys) -657 4G allele (rs1799889) (+) (p=0.0189) (exponential coefficient of survival regression 3.35, 95% CI 1.22-9.22) ACE I/D (rs4340) (-) AGT M235T T allele (rs 699) (+) (OR 1.33, 95% CI 1.04-1.70, p=0.02) AGTR1 C allele and CC (rs5186) (+) C allele (OR 1.87, 95% CI 1.49-2.35, p<0.0001) ACE (rs4340) (-) D allele (OR 0.92, 95% CI 0.70-1.20, p=0.59) ACE D allele (rs4340) (+) (OR 1.34, 95% CI 1.07-1.69, p=0.01) AGT M235T (rs699) (+) (OR 0.74, 95% CI 0.59-0.94, p=0.01) AGTR1 A1166C (rs388915) (-) TNF -308 AA, AG, GG (rs1088629) (-) TGFB1 (codon 10) TT (rs1800470) (+) (OR 5.31, 95% CI 3.77-7.02, p<0.001) IL10 (-1082) GG (rs1800896) (+) (OR 2.35, 95% CI 1.67-3.15, p<0.01) Hyperuricemia: TGFB1 G/G (rs1800471) (+) (p=0.0013) TGFB1 (codon 10) (rs1800470) (-) IL10 AG (-1082) (rs1800896) (+) (p=0.0022) Type 2 or steroid-induced diabetes mellitus: IFNG (+874 AA) (rs2430561) (+) (p=0.0127) IL10 (-1082 A/G) (rs1800896) (-) IL1RN 2-repeat allele (VNTR 2 copies ) (+) (OR 1.46, 95% CI 1.19-1.78, p<0.01) IL1B (-511) (rs16944) (-) tacrolimus group had decreased insulin secretion.27 The exact mechanism of calcineurin inhibitor-induced toxicity to the beta cell is unknown. Login to comment