ABCC8 p.Ser1446Arg
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No.
Sentence
Comment
184
Mutations within the ABC signature motif of NBF2 of SUR1 (S1482R) and SUR2B (S1446R) abolished the channel activation by MgADP, whereas the corresponding mutation of NBF1 of SUR1 (S830R) and SUR2B (S809R) did not [96].
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ABCC8 p.Ser1446Arg 15910875:184:77
status: NEW187 Interestingly, the serine mutation of NBF1 (S809R) and NBF2 (S1446R) of SUR2A did not affect the channel activation by MgADP [96].
X
ABCC8 p.Ser1446Arg 15910875:187:61
status: NEW
PMID: 12169627
[PubMed]
Matsuo M et al: "Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding."
No.
Sentence
Comment
204
For example, it might in¯uence the local structure of NBD2 such that it is able to tolerate the effect of the serine to arginine mutation at residue 1446.
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ABCC8 p.Ser1446Arg 12169627:204:114
status: NEW239 Mutations in the NBD2 linker were: SUR1-S1482R and SUR2-S1446R (S2R); SUR1-Q1426A, SUR1-H1537A.
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ABCC8 p.Ser1446Arg 12169627:239:56
status: NEW