ABCMdb

ABCC8 p.Tyr179Trp

None has been submitted yet.

Publications

PMID: 21685390 [PubMed] Marquer C et al: "Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor."

No. Sentence Comment

271 This distance is similar to the distance between the two MT7 binding sites centered on Tyr-179/Trp-400 of each protomer in our model of MT7-hM1 dimer complex (Fig. 8B). Login to comment
277 In this case, the distance between the two MT7 binding sites (Tyr-179/Trp-400) is too large (35 Å) to receive the tips of MT7 loops (Fig. 8C). Login to comment
280 Fig. 8D shows the variation of the distances between the MT7 binding sites (Tyr-179/Trp-400) of both protomers as a function of the angle of rotation of each protomer around their vertical axis. Login to comment
283 This is due to the fact that Tyr-179/Trp- FIGURE 5. Login to comment
336 Therefore, the MT7-hM1 dimer recognition site is composed of three patches on MT7 (the tips of the three loops) and two patches on the hM1 side (the binding sites of the two protomers; Tyr-179/Trp-400), forming a totalinterfaceareaequalto2400Å2 .Thisvalueisclosetothemean valueoftheprotein/proteininterfaceareasreportedfortwo-patch interactions (2500 Å2 ) (73). Login to comment
350 B, hM1 dimer conformation calculated from our experimental data viewed from the extracellular face (Tyr-179/Trp-400 in green). Login to comment
351 C, hM1 dimer conformation based on the CXCR4 chemokine structure viewed from the extracellular face (Tyr-179/Trp-400 in yellow). Login to comment
352 D, measurements of the distancesbetweenthetwocentersofgravityoftheprotomersofthereceptor (E) and the two centers of mass of the MT7 binding sites (Tyr-179/Trp-400) of the protomers (f) during the step by step rotation of each protomer around their vertical axis. Login to comment