ABCB1 p.Pro1194Ala
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PMID: 9614062
[PubMed]
Loo TW et al: "Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions."
No.
Sentence
Comment
48
Misprocessing mutations are located throughout the molecule; these include the transmembrane domains (e.g. A123L), intracellular (e.g. E243A) and extracellular (e.g. Y853C) loops, the linker region (e.g. E707A), and both nucleotide-binding domains (e.g. G427C, P1194A).
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ABCB1 p.Pro1194Ala 9614062:48:261
status: NEW
PMID: 15530432
[PubMed]
Loo TW et al: "Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein."
No.
Sentence
Comment
69
A processing mutation in NBD2 is P1194A, while P709G is in the linker region.
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ABCB1 p.Pro1194Ala 15530432:69:33
status: NEW70 Although the processing mutations (G251V, G300V, DY490, P709A, G722A, F804A, and P1194A) are located in different segments of P-gp, all the mutants could be rescued when expressed with drug substrates such as cyclosporin A.
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ABCB1 p.Pro1194Ala 15530432:70:81
status: NEW90 We then compared the abilities of cyclosporin A, thapsigargin, and curcumin to induce maturation of P-gp processing mutants G251V, G300V, DY490, P709A, G722A, F804A, and P1194A.
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ABCB1 p.Pro1194Ala 15530432:90:170
status: NEW