ABCB1 p.His61Phe
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PMID: 9220975
[PubMed]
Taguchi Y et al: "Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1/P-glycoprotein."
No.
Sentence
Comment
8
We also showed that the replacement of His61 by Phe and Lys greatly impaired the efflux of calcein AM, while the replacement had no effect on the efflux of rhodamine 123.
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ABCB1 p.His61Phe 9220975:8:39
status: NEW91 The replacement of His61 by Phe, Met, or Trp, which has a nonpolar and bulkier side chain than His, reduced resistance to Vbl and increased resistance to Col, Adr, and VP16, resulting in a resistance order of Adr ≈ Col > Vbl ≈ VP16.
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ABCB1 p.His61Phe 9220975:91:19
status: NEW