ABCB1 p.His61Lys
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PMID: 9220975
[PubMed]
Taguchi Y et al: "Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1/P-glycoprotein."
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8
We also showed that the replacement of His61 by Phe and Lys greatly impaired the efflux of calcein AM, while the replacement had no effect on the efflux of rhodamine 123.
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ABCB1 p.His61Lys 9220975:8:39
status: NEW92 The replacement of His61 by Lys or Arg, which have a bulkier and basic side chain, reduced resistance to Vbl and Adr and increased resistance to Col and VP16, resulting in a resistance order of Col > VP16 ≈ Vbl > Adr.
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ABCB1 p.His61Lys 9220975:92:19
status: NEW136 The ability to confer resistance to Adr of mutant P-glycoproteins showed a characteristic dependence on the nature of the amino acids: although cells expressing mutants in which His61 was replaced by amino acids with side chains larger than His showed higher (more than 2-fold than that of the wild-type) resistance to Adr, cells expressing mutants in which His61 was replaced by Lys or Arg showed markedly lower resistance to Adr.
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ABCB1 p.His61Lys 9220975:136:358
status: NEW